RESUMO
Pregnant Wistar rats received a therapeutic dose (0.72 mg/kg body weight) of intramuscular sulfadoxine-pyrimethamine on days 5, 12, and 19 of gestation. The treated animals showed elevated neutrophilic lobe average and increased urinary excretion of formiminoglutamic acid (FIGLU) as compared with controls (p < 0.001), confirming folic acid deficiency due to sulfadoxine-pyrimethamine treatment. Complete embryo resorption occurred in the treatment group, while the control animals littered normally. These findings imply that sulfadoxine-pyrimethamine should be used with utmost caution in early pregnancy as this regimen can lead to folic acid deficiency and consequent pregnancy wastage.
Assuntos
Antimaláricos/intoxicação , Doenças Fetais/induzido quimicamente , Pirimetamina/intoxicação , Sulfadoxina/intoxicação , Animais , Combinação de Medicamentos , Embrião de Mamíferos/efeitos dos fármacos , Feminino , Deficiência de Ácido Fólico/induzido quimicamente , Gravidez , Ratos , Ratos WistarRESUMO
A 39 year-old man with malaria due to Plasmodium falciparum received 3500 mg mefloquine over 3 days, in addition to 3250 mg chloroquine and 175/3500 mg sulfadoxine/pyrimethamine. He developed severe neuropsychiatric symptoms and had to be hospitalized. Treatment with diazepam, haloperidol and thioridazine achieved relief of the severe symptoms after 4 days. The patient was still suffering from discrete neuropsychiatric symptoms 8 months after treatment.
